Nitrile compounds

ABSTRACT

An improved process of producing known 5-pyrimidine carboxylic acids which have in 4-position a basic group, such as the 2,3dimethyl anilino, 3-trifluoro methyl anilino, dimethylamino, anilino, N-methyl anilino, and other groups, by using the readily available malonic acid dinitrile or dimethylamino methylene malonic acid dinitrile and dimethylformamide chloride as starting reactants, reacting said reactants at a temperature between 10*C. and 110*C., preferably in the presence of an inert solvent to yield the heretofore unknown 1-dimethylamino-3-chloro-4-cyano-2azapentadiene-5-dimethyliminium chloride which is preferably purified by conversion into the perchlorate, replacing the chlorine atom in 3-position by an amino group to yield the heretofore unknown corresponding 1-amino-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(1) compound, causing ring closure to the corresponding 4-amino-5-cyano pyrimidine compound by reaction with ammonia, and saponifying the cyano group to the carboxyl group. The final products are known antiphlogistic, analgesic, and antirheumatic drugs. Examples of such intermediates and final products are: A. 1-Dimethylamino-3-chloro-4-cyano-2-azapentadiene-5dimethyliminium perchlorate -&gt; 1-(3&#39;&#39;-trifluoro methyl anilino)1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(1) perchlorate -&gt; 4-(3&#39;&#39;-trifluoro methyl anilino)-5cyano pyrimidine -&gt; 4-(3&#39;&#39;-trifluoro methyl anilino) pyrimidine5-carboxylic acid; B. 1-Dimethylamino-3-chloro-4-cyano-2-azapentadiene-5dimethyliminium perchlorate -&gt; 1-(2&#39;&#39;,3&#39;&#39;-dimethylanilino)-1dimethylamino methylene amino-3-dimethyliminium-2-cyano propene(1) perchlorate -&gt; 4-(2&#39;&#39;,3&#39;&#39;-dimethyl anilino)-5-cyano pyrimidine -&gt; 4-(2&#39;&#39;,3&#39;&#39; -dimethylanilino)pyrimidine-5-carboxylic acid. In a similar manner there are obtained 4-dimethylamino-5-cyano pyrimidine -&gt; 4-dimethylamino pyrimidine-5-carboxylic acid or 1-(N-methylanilino)-1-dimethylamino methylene amino-3dimethyliminium-2-cyano propene-(1) perchlorate -&gt; 4-(N-methyl anilino)-5-cyano pyrimidine -&gt; 4-(N-methyl anilino) pyrimidine5-carboxylic acid. The process has the advantage over known processes of producing the respective pyrimidine-5-carboxylic acids that the starting materials are readily available, that the reaction steps are carried out in a simple manner and without any considerable expenditures, and that the resulting intermediates are obtained in a pure state and a high yield.

[451 Sept. 18,1973

[ NITRILE COMPOUNDS [75] Inventors: Christian Jutz, Munich, Germany; Werner Mueller, Germantown, Pa.

[7 3] Assignee: Byk-Gulden Lomberg Chemische Fabrik Gmbll, Konstanz, Germany [22] Filed: May 22, 1970 [21] Appl. No.: 38,646

Related US. Application Data [62] Division of Ser. No. 674,695, Sept. 26, 1967, Pat. No.

[52] US. Cl...... 260/465 E, 260/239.75, 260/256.5, 260/397.7, 260/429, 260/465.5 R

[51] Int. Cl. C07c 121/42, C07c 121/52 [58] Field of Search 260/465.5, 465 E, 260/429 [56] References Cited UNITED STATES PATENTS 3,095,441 6/1963 Kliss 260/465.5 R

3,138,631 6/1964 Frazza et a1. 260/465 3,406,170 10/1968 Papa 260/465.5 X

3,414,580 12/1968 Hohn 260/4655 R X Primary Examiner.l. P. Brust Attorney-Erich M. Radde, Charles A. McClure, Ge-

rard J. Weiser and Alfred Stapler [5 7] ABSTRACT by conversion into the perchlorate, replacing the chlorine atom in 3-position by an amino group to yield the heretofore unknown corresponding l-amino-ldimethylamino methylene amino-3-dimethy1iminium- Z-cyano propene-(l) compound, causing ring closure to the corresponding 4-amino-5-cyano pyrimidine compound by reaction with ammonia, and saponifying the cyano group to the carboxyl group. The final products are known antiphlogistic, analgesic, and antirheumatic drugs.

' Examples of such intermediates and final products are:

a. 7 l-Dimethylamino-3-chloro-4-cyano-2- azapentadiene -5-diinethyliminium perchlorate 1- (3'-trifluoro methyl a nilinoyl-dimethy1amino methylene amino-3-dimethyliminium-2-cyano propene-( l perchlorate 4-,( 3 '-tri fluoro methyl anilino )-5-cyano, pyrimidine 4-(3'-trifluoro methyl anilino) pyrimidine-S-carbdiflic acid;

b. 1-Dimethylamino-3-chloro-4-cyano-2- azapentadiene-S-dimethyliminium perchlorate --+l- (2 ',3 '-dimethylanilino)- l -dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(l) perchlorate 4-(2',3'-dimethyl anilino)-5-cyano pyrimidine-- 4-(2,3'-dimethylanilino)pyrimidine-S- carboxylic acid.

In a similar manner there are obtained 4-dimethylamino-5-cyano pyrimidine 4-dimethylamino pyrimidine-S-carboxylic acid or 1 -(N-methy1anilino 1 -dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-( l perchlorate 4-(N-methyl anilino)-5-cyano pyrimidine 4-(N-methyl anilino) pyrimidine-S-carboxylic acid.

The process has the advantage over known processes of producing the respective pyrimidine-S-carboxylic acids that the starting materials are readily available,

that the reaction steps are carried out in a simple manner and without any considerable expenditures, and that the resulting intermediates are obtained in a pure state and a high yield.

7 Claims, No Drawings NITRILE COMPOUNDS This application is a division of our application Ser. No. 674,695, now U.S. Pat. No. 3,523,119 filed Sept. 26, 1967.

BACKGROUND OF INVENTION stituted by a dimethylanilino group are described in U.S. Pat. No. 3,254,086.

Pyrimidine carboxylic acids which are substituted by an anilino group substituted in their phenyl ring by the trifluoro methyl groups are produced according to U.S. Pat. No. 3,254,087.

The compounds described in said patents possess valuable pharmaceutical properties and are useful antiphlogistic, analgesic, and antirheumatic agents.

The known processes of producing said compounds have a number of disadvantages. The starting materials used are of a complicated structure and are notreadily available. The yield is low. The process steps are quite complicated and require considerably considerable Thus preparation of such pyrimidine carboxylic acid compounds on a large scale is rather difficult, if not impossible.

SUMMARY OF THE INVENTION wherein the 3-chlorine atom is replaced by a secondary or tertiary amino group.

Other objects and advantageous features. of the present invention will become apparent as the description proceeds.

The process according to the present invention has proved of value in the preparation of substituted pyrimidine carboxylic acids of Formula I wherein R, is hydrogen, alkyl with one to five carbon atoms,

or benzyl and R is alkyl with one to five carbon atoms or the group wherein R R and R are the same or different substituents, such as hydrogen, halogen, especially chlorine or bromine, alkyl with one to five carbon atoms, alkenyl with two to five carbon atoms, or the trifluoro methyl, nitro, lower alkoxy, or sulfonamido group. In principle, such substituted pyrimidine carboxylic acid compounds are produced as illustrated by the reaction equations given on the flow sheet. According to said equations about one mole of malonic acid dinitrile of Formula II are reacted with about two moles of dimethyl fonnamide chloride of Formula III, preferably in an inert organic solvent such as a halogenated aliphatic hydrocarbon, for instance, chloroform, carbon tetrachloride, triethylene chloride, or an aromatic hydrocarbon, for instance, benzene or toluene, at a temperature between about 10C. and about 110C. and preferably between about 10C. and about C. (reaction step A). Thereby, l-dimethylamino-3-chloro-4- cyano-2-azapentadiene-5-dimethyliminium chloride is obtained. Said compound can readily be converted into its perchlorate of Formula IV by reaction with sodium perchlorate. The perchlorate is obtained in a good yield and in a substantially pure state. In place of the perchlorate, there may be prepared other salts, such as the picrate, styphnate, picronolote, hexachloro platinate,

and others although the perchlorate is the preferred salt. I

In place of malonic acid dinitrile, the reaction may also becarried out by using dimethylamino methylene malonic acid dinitrile of Formula V as the one reaction component said compound V is reacted with one mole of dimethyl formamide chloride of Formula II] and yields also I- dimethylamino-3-chloro-4-cyano-2-azapentadiene-5- dimethyliminium perchlorate of Formula IV. The dimethylformamide chloride is preferably used in statu exchange of chlorine in the compound of Formula V by the amino group is also effected in the presence of an inert organic solvent as mentioned hereinabove. In this manner, the ldimethylamino-3-amino-4-cyano-2-azapentadiene5- dimethyliminium perchlorate of Formula VII, which may also be designated as N,N-dimethyl-- dimethylamino-3-amino-2-cyano-4-azapenta-2,4-diene inimium perchlorate or as l-amino-l-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-( l) perchlorate, is obtained. When using, for instance, 3-trifluoro methylaniline as amino in this exchange reaction of step B, l-(3-trifluoro methyl anilino l -dimethylamino methylene-3-dimethyliminium-2- cyano propene-( 1) perchlorate is obtained.

According to reaction step C ring closure is effected on treating said compounds of Formula VII with ammonia, preferably while heating. Thereby, correspondingly 4-substituted 5-cyano pyrimidine compounds of Formula VIII are formed.

On heating the chloro compound of Formula VII with aqueous ammonium chloride solution or with dilute ammonia solution, 4-dimethylamino-5-cyano pyrimidine is directly obtained by ring closure and substitution of the chlorine atom by the dimethylamino group.

In order to produce the 4-basically substituted pyrimidine-5- carboxylic acid compounds of Formula IX, the c'yano group in the compound of Formula VIII is saponified according to reaction step D preferably by means of aqueous sulfuric acid or alcoholic alkali metal hydroxide solution.

As stated above, this chemically novel process has the advantage over the processes described in the cited US. Patents, that readily available starting materials of simply structure are used. All the reaction steps are very simple and can be carried out without any considerable expenditure in labor, energy, time, and apparatus. The yield is in general excellent and the reaction products can readily be obtained in a pure state. The process according to this invention thus represents a noteworthy technical advance in the art of synthesizing such substituted pyrimidine carboxylic acid compounds.

BRIEF DESCRIPTION OF DRAWINGS As stated above, the flow sheet illustrates the process of this invention and the reaction steps involved.

DETAILED DESCRIPTION OF INVENTION The following examples serve to illustrate the present invention without, however, limiting the same thereto.

Example I l-Dimethylamino-5-dimethyliminium-3-chloro-2- cyano- 4-azapentadiene-( 1,3) perchlorate (Formula IV) 13.2 g. of malonic acid dinitrile dissolved in 20 cc. of chloroform are added drop by drop to a formylation mixture of 47.5 g. of dimethylformamide and 51.3 cc. of oxalychloride in 120 cc. of chloroform. The mixture is heated to 64C. for a short period of time. Thereby vigorous reaction takes place, hydrogen chloride evolves, and the initially yellow reaction mixture becomes dark brown. After the reaction has ceased, the chloroform is removed by vacuum distillation. The pasty residue is extracted twice, each time with 90 cc. of ether. A solution of 25 g. of sodium perchlorate in 200 cc. of water is then added while stirring and cooling. Thereby, yellow crystals precipitate. They are filtered off by suction and are recrystallized from a mixture of acetonitrile and ether (lzl They correspond to the empirical formula [C H N Cl]ClO Melting point: 171C. Yield: 51 g. corresponding to 8| percent of the theoretical yield.

Example 2 The same compound is obtained by heating 2.4g. of dimethylamino methylene malonic acid dinitrile and 3.84 g. of dimethylformamide chloride, obtained from 2.2 g. of dimethylformamide and 2.0 cc. of oxalylchloride, in 20 cc. of chloroform for about 1 hour. The reaction mixture is worked up as described in Example I 5 g. of the perchlorate of l-dirnethylamino-S-dimethyliminium-3- chloro-2-cyano-4-azapentadiene-( 1,3), corresponding to 80 percent of the theoretical yield, are obtained.

Example 3 l-(3'-trifluoro methyl anilino)-l-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-( l) perchlorate (Formula VII) A mixture of 31.25 g. of the perchlorate obtained according to Example 1 or 2, 49.0 g. of 3-trifluoro methyl aniline, and 100 cc. of chloroform are boiled under reflux for 30 minutes. The chloroform is distilled off. The residue is extracted twice, each time with cc. of ether in order to remove unreacted 3-trifluoro methyl aniline. The resulting residue can be used without further example.

Example 4 4-(3'-Trifluoro methyl anilino)-S-cyano pyrimidine (Formula VIII) 200 cc. of an aqueous 25 percent ammonia solution are added to the residue obtained according to Example 3. The mixture is boiled for 20 minutes. After cooling, the 4-(3'-trifluoro methyl aniline)-5-cyano pyrimidine crystallizes. Its melting point, after recrystallization from ethanol, is l64-l65C. Yield: 19.1 g. corresponding to 72.3 percent of the theoretical yield.

Example 5 4-(3'-Trifluoro methyl anilino) carboxylic acid (Formula IX) 2.1 g. of 4-(3-Trifluoro methyl anilino)-S-cyano pyrimidine obtained according to example 4 are heated on the boiling water bath with 42.0 g. of percent sulfuric acid for 8 hours. The reaction mixture is then poured on about g. of ice. The white crystalline precipitate is filtered off by suction, washed with water until of neutral reaction and dissolved in 2 N sodium hydroxide solution. 2 N hydrochloric acid is added to said alkaline solution until its pI-I-value is adjusted to a pH of 6.3. Thereby, 4-(3'-trifluoro methyl anilino )pyrimidine-S-carboxylic acid crystallizes. Melting point: 231-232C. Yield: 1.73 g. corresponding to 76.5 percent of the theoretical yield.

Example 6 3.1 g. of the perchlorate obtained according to Example l or 2 are heated under reflux with 12.1 g. of 2,3-dimethyl aniline and 20 cc. of chloroform for 20 minutes. Thereafter, the reaction mixture is concenpyrimidine-5- I trated by evaporation in a rotating evaporator. The residue is digested three times, each time with 30 cc. of ether. The resulting residue is the l-(2',3-dimethylanilino)-l-dimethylamino methylene amino-3- dimethyliminium-2-cyano propene-(l) perchlorate which can be used without further purification in the following reaction step.

Example 7 4-(2',3'-dimethylanilino)-5-cyano pyrimidine (Formula VIII) The reaction product obtained according to example 6 is mixed with 50 cc. of concentrated ammonia. The mixture is heated on the boiling water bath for 20 minutes. The aqueous layer is removed by decanting and the residue is recrystallized first from a mixture of 20 cc. of ethanol and 5 cc. of water and then twice from methanol. 4-(2',3'-Dimethylanilino)-5-cyano pyrimidine is obtained in pure condition. Melting point: 202203.5C. Yield: 1.8 g. corresponding to 80 percent of the theoretical yield.

Example 8 4-(2',3'-Dimethylahilino) acid (Formula IX) 1.5 g. of the nitrile obtained according to Example 7 are treated on the boiling water bath with 20 cc. of 75 percent sulfuric acid for 2% hours. The resulting reac pyrimidine-S-carboxylic 7 tion mixture is poured on about 60 g. of ice. The precipitate is filtered off by suction, dissolved in 40 cc. of 2 N sodium hydroxide solution, and filtered. The filtrate is acidified to a pH of 6.3 by the addition of 2 N hydrochloric acid. The resulting precipitate is filtered off by suction, washed with a small amount of water, and recrystallized from a mixture of dimethylformamide and water (1:1). Thereby, the above-mentioned pyrimidine carboxylic acid is obtained in pure condition with k mole of water of crystallization. Melting point: 251-252 C. Yield: 1.1 g. corresponding to 68 percent of the theoretical yield.

Example 9 4-Dimethylamino-5-cyano pyrimidine 6.3 g. of ldimethylamino-5-dimethyliminium-3- chloro-2-cyano-4-azapentadiene-( 1,3) perchlorate obtained according to Example 1 or 2 are heated on the boiling water bath with 50 cc. of a saturated ammonium chloride solution and 1 cc. of concentrated ammonia solution for 10 minutes. On cooling, needles of 4-dime thylamino-5-cyano pyrimidine precipitate from the resulting clear reaction solution. The residue of the combined and dried extracts is recrystallized from isopropanol or a small amount of water. White needles of the melting point 114C. are obtained. Yield: 1.7 g. corresponding to 58 percent of the theoretical yield.

Example 10 l-( N-methyl anilino)-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-( l perchlorate.

3.13 g. of l-dimethylamino-5dimethyliminium-3- chloro-2-cyano-4-azapentadiene-( 1,3) perchlorate obtained according to Examples .1 or 2 and 3.2 g. of methylaniline are heated in a small amount of chloroform for minutes. The reaction mixture is triturated with ether whereby l-(N-methyl anilino)-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene 1) perchlorate and methyl aniline hydrochloride precipitate as crystals. On recrystallization from a mixture of acetonitrile and acetic acid ethyl ester, the perchlorate melts at 192C.

Example 11 4-(N-methyl anilino-S-cyano pyrimidine The compound obtained according to Example 10 is treated with cc. of dilute ammonia and the reaction mixture is worked up as described, for instance, in Example 4. White needles of the above mentioned substituted pyrimidine nitrile are obtained. Melting point: 92C. on recrystallization from a mixture of ethanol and water. Yield: 1.7 g. corresponding to 81 percent of the theoretical yield.

Example 12 l-Anilino-l-dimethylamino methylene amino-IL dimethyl iminium-Z-cyano propene-( l perchlorate The procedure is the same as described in Example 10, whereby, in place of methyl aniline, 3 g. of aniline are reacted.

Example 13 4-Anilino-5-cyano pyrimidine The procedure is the same as described in Example 11, whereby, however, the reaction product obtained according to Example 12 is employed as starting material in the ring closure reaction. The resulting 4-anilino- 5-cyano pyrimidine is obtained in the form of white needles of the melting point of 168C.

Of course, the nitriles obtained according to Examples 9, 1 l, and 13 can readily be converted into the corresponding 4-basically substituted pyrimidine-5- carboxylic acids by saponification with dilute sulfuric acid as described in Examples 5 and 8. Saponification of said nitriles to the corresponding carboxylic acids can also be effected by means of alcoholic sodium or potassium hydroxide solution.

In place of 3-trifluoro methyl aniline, 2,3-dirnethyl aniline, methyl aniline, and aniline, there may be employed equimolecular amounts of other primary and secondary lower aliphatic amines or aromatic aminos, such as dimethylamine, n-butylamine, allylamine, 0-, m-, or p-toluidines, p-ethyl aniline, p-isobutyl aniline, 0-, m-, or p-chloro anilines, o-, m-, or pnitro anilines, 2,4-dichloro aniline, 2,4,6-trichloro aniline, 2,4- or 2,6-

dinitro anilines, 2,6-dinitro p-toluidine, N-ethyl, N- I isopropyl, N-butyl or N-allyl anilines, oor p-anisidines, N-methyl-o-anisidine, p-phenetidine, p-sulfonamido aniline, p-sulfonyl-N-butylamido aniline, and others, while otherwise the procedure is the same as described in the preceding examples.

In place of the perchlorate of l-dimethylamino-S- dimethyliminium3-chloro-2-cyano-4-azapentadiene- (1,3) prepared as described in Examples 1 and 2, there may also be prepared the styphnate, the picrate, the picronolate, the hexachloro platinate of said compound, although the perchlorate is the preferred salt. Such other salts are prepared in a manner known to the art. They can also be used for reaction with the primary and secondary amines as described for the perchlorate.

It may be mentioned that the dimethyl formamide chloride is preferably used in state nascendi since it is not stable and cannot be stored. The dimethylamino methylene malonic acid dinitrile used in Example 2 as the one reactant is prepared according to Meerwein et al. Liebigs Ann.Chem. vol. 641, page 527 (1961) or Eiden Angew. Chemie" vol. 72, page 71 (1960).

Of course, many changes and variations in the reactants and solvents used, the reaction conditions, temperature and duration, in the methods of isolating and purifying the reaction products, and the like may be made by those skilled in the art in accordance with the principles set forth herein and in the claims annexed hereto.

n I Flow Sheet of Process of Invention HzC(CN)z 2[(crr,),N=cHc1]+c1 III CE, (IJN VII VIII

COOH

What is claimed is:

l. The l-dimethyl amino methylene amino-3- dimethyl-iminium-Z-cyano propene-( 1) salt of the formula wherein R, is a member selected from the group consisting of hydrogen, alkyl of one to five carbon atoms, and benzyl and R is a member selected from the group consisting of alkyl of one to five carbon atoms and the group wherein R R and R are members selected from the group consisting of hydrogen, chloro, bromo, alkyl of one to five carbon atoms, alkenyl of two to five carbon atoms, trifluoro methyl, nitro, lower alkoxy, and sulfonamido, while X is an anion.

2. The salt of claim 1 wherein R, is hydrogen or alkyl of one to five carbon atoms, R is alkyl of one to five carbon atoms, R R and R are selected from hydrogen, chloro, alkyl of one to five carbon atoms, trifluoro methyl, nitro, lower alkoxy and sulfonamido 3. The salt of claim 2 which is the chloride, perchlorate or picrate.

4. l-dimethylamino-3-chloro-4-cyano-2-azapental,3-diene-5-dimethyliminium perchlorate.

5. l-(3'-Trifluoro methyl anilin0)-1-dimethylamino methylene amino-3-dimethyliminium-2'cyano propene-( l perchlorate.

6. l(2',3-Dimethyl anilino)-l-dimethylamino methylene aminc-3-dimethyliminium2-cyano propene-( l) perchlorate.

7. l-(N-Methyl anilino)-l-dimethylamin0 methylene amino-3-dimethyliminium-2-cyano propene-(l) perchlorate.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No, 317591976 D d August 4, 1974 lnventofls) Christian Jutz, Werner Mueller It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

In the heading of the Patent, on the page containing the Abstract, the following should appear:

"Claim priority, application Germany, June 2, 1967,

Signed and Scaled this twenty-eight D ay Of October I 975 [S AL] Attest:

RUTH C. MASON C. MARSHALL DANN Arresting Office) (ummissimwr oj'Parents and Trademarks 

2. The salt of claim 1 wherein R1 is hydrogen or alkyl of one to five carbon atoms, R2 is alkyl of one to five carbon atoms, R3, R4 and R5 are selected from hydrogen, chloro, alkyl of one to five carbon atoms, trifluoro methyl, nitro, lower alkoxy and sulfonamido
 3. The salt of claim 2 which is the chloride, perchlorate or picrate.
 4. 1-dimethylamino-3-chloro-4-cyano-2-azapentA- 1,3-diene-5-dimethyliminium perchlorate.
 5. 1-(3''-Trifluoro methyl anilino)-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(1) perchlorate.
 6. 1(2'',3''-Dimethyl anilino)-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(1) perchlorate.
 7. 1-(N-Methyl anilino)-1-dimethylamino methylene amino-3-dimethyliminium-2-cyano propene-(1) perchlorate. 